Study on protective effect and mechanism of fufang tangshang gao on deep grade II skin burn in rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the protective effect and mechanism of Fufang Tangshang Gao (FFTSG) on deep grade II burn wounds in rats.</p><p><b>METHOD</b>The deep grade II skin burn model was established. FFTSG was adopted for wounds once everyday for 21 d. Samples were collected at different time points after burn to determine the wound healing rate, the wound tissues water content, VEGF, TNF-alpha and IL-1.</p><p><b>RESULT</b>At different time points, FFTSG (0.4, 0.2, 0.1 g x g(-1)) could increase the wound healing rate and VEGF content and decrease the tissues water content, TNF-alpha and IL-1.</p><p><b>CONCLUSION</b>FFTSG shows a notable protective effect on deep grade II burn wounds in rats by obviously promoting the wound healing and decreasing the wound tissues water content. Its mechanisms may be related with the increase in VEGF synthesis and release of wound tissues and the decrease in TNF-alpha and IL-1 in rat blood serum.</p>