A new C-28 nortriterpenoid from fruits of Leonurus japonicus / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the chemical constituents from the fruits of Leonurus japonicus.</p><p><b>METHOD</b>The compounds were extracted by 70% methanol, then isolated and purified by column chromatography on silica gel, RP-18, Sephedax LH-20 and HPLC. Their structures were determined on the basis of spectroscopic data and physicochemical property.</p><p><b>RESULT</b>Two 28-noroleanane-derived spirocyclic triterpenoids including a new acylated nortriterpenoid were isolated and identified as (17R)-19(18 --> 17)-abeo-2alpha,18beta,23-trihydroxy-3beta-E-feruloyoxy-28-norolean-12-ene (1) and phlomistetraol B (2).</p><p><b>CONCLUSION</b>Compound 1 is a new compound,named as leonujaponin A. Both compounds 1-2 are isolated for the first time from Leonurus plants.</p>