Relationship between specific immunocyte and pseudoanaphylactoid reactions induced by Shuanghuanglian injection / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1898-1900, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-338737
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between specific immunocyte and pseudoanaphylactoid reactions (PR) induced by Shuanghuanglian injection (SHLI).</p><p><b>METHOD</b>ICR mice, SCID mice and BALB/C athymic mouse were divided into different test groups, the mice were intravenously injected with solutions of different concentration of SHLI, positive control Compound 48/80 and normal sodium. All test substances were mixed with 0. 4% Evans blue. The reaction and vascular permeability of the ears were observed and measured 30 min after SHLI injected.</p><p><b>RESULT</b>SHLI of 300, 600 mg x kg(-1) caused obvious vascular hyperpermeability in ICR mice, but the same dose of SHLI didn't cause vascular hyperpermeability in SCID mice and BALB/C athymic mouse.</p><p><b>CONCLUSION</b>SHLI in equivalent and 2 times the clinical dose can cause PR in ICR mice, but the same dose of SHLI can't cause PR in SCID mice and BALB/C athymic mouse, so specific immunocyte maybe take part in the SHLI-induced PR.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Mice, SCID
/
Allergy and Immunology
/
Toxicity
/
Anaphylaxis
/
Immune System
/
Injections
/
Methods
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Mice, Inbred BALB C
/
Mice, Inbred ICR
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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