Experimental study on anaphylactoid reactions of guinea pig induced by danshen injection and its components / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1894-1897, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-338738
ABSTRACT
<p><b>OBJECTIVE</b>To compare the anaphylactoid effect of Danshen injection and its components on guinea pig.</p><p><b>METHOD</b>Applying active systemic anaphylaxis (ASA) tests, the corresponding experimental injections were administrated to guinea pigs to sensitized, and allergen with double doses was injected to stimulate in the 11 days after the last sensitized. The anaphylaxis situation of guinea pigs was observed.</p><p><b>RESULT</b>Danshen injection and its components are suspicion on guinea pigs, while negative reaction was observed on guinea pigs which injected by the liquid excipients of Danshen injection.</p><p><b>CONCLUSION</b>Danshen injection using the ultrafiltration method still have some antigenic impurities which cannot be removed completely, and this may be one of the reasons for anaphylactic reaction.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenanthrolines
/
Drugs, Chinese Herbal
/
Chemistry
/
Salvia miltiorrhiza
/
Toxicity
/
Guinea Pigs
/
Anaphylaxis
/
Injections
/
Methods
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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