Study on intestinal absorption of mollugin and purpurin in rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the absorption kinetic characteristics of mollugin and purpurin in each intestinal segment of rats.</p><p><b>METHOD</b>The in situ single-way perfusion rat model was established to study absorption characteristics of mollugin and purpurin in each intestinal segment of rats. The volume of recirculation fluid was regulated by phenol red.</p><p><b>RESULT</b>Different quality concentrations (12.33, 24.66, 49.32 mg x L(-1)) of mollugin and (8.455, 16.91, 33.82 mg x L(-1)) purpurin showed a concentration gradient of absorption dose in each intestinal segment, with the osmotic coefficient increasing to more than 0.2 x 10(-4) cm x s(-1). In the same concentration, mollugin and purpurin showed an identical trend of P(eff) in each intestinal segment in the order of colon > duodenum > ileum > jejunum, with a significant difference (P < 0.05).</p><p><b>CONCLUSION</b>Mollugin and purpurin are highly permeable in rat intestinal segments, with absorption in each segment, while the specific absorption existed in the colon segment.</p>