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Pharmacokinetics of Danshen multi-component osmotic pump tablets in Beagle dogs / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1761-1764, 2012.
Article in Chinese | WPRIM | ID: wpr-338766
ABSTRACT
<p><b>OBJECTIVE</b>To study the variation in plasma concentration after oral administration of Danshen multi-component osmotic pump tablets in Beagle dogs with conventional Danshen tablets as the control preparation, in order to assess the sustained release of Danshen multi-component osmotic pump tablets.</p><p><b>METHOD</b>HPLC was adopted for determination, with Shimadzu's ODS-SP column (4.6 mm x 150 mm, 5 microm), flow rate of 1 mL x min(-1), and column temperature of 30 degrees C. Protein in plasma samples of tanshinone II(A) and salvianolic acid B was removed by ethyl acetate extract and acetone precipitation method respectively. Their pharmacokinetic parameters were calculated based on determination results.</p><p><b>RESULT</b>The methodology study on the two constituents with different polarity showed conformity to the requirements. Compared with conventional Danshen tablets, Danshen multi-component osmotic pump tablets showed decrease in Cmax and extension in Tmax after oral administration in Beagle dogs.</p><p><b>CONCLUSION</b>Danshen multi-component osmotic pump tablet has a good sustained-release effect compared with conventional Danshen tablets.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Osmosis / Tablets / Time Factors / Drugs, Chinese Herbal / Pharmacokinetics / Chemistry / Salvia miltiorrhiza Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osmosis / Tablets / Time Factors / Drugs, Chinese Herbal / Pharmacokinetics / Chemistry / Salvia miltiorrhiza Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2012 Type: Article