Pharmacokinetics of Danshen multi-component osmotic pump tablets in Beagle dogs / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1761-1764, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-338766
ABSTRACT
<p><b>OBJECTIVE</b>To study the variation in plasma concentration after oral administration of Danshen multi-component osmotic pump tablets in Beagle dogs with conventional Danshen tablets as the control preparation, in order to assess the sustained release of Danshen multi-component osmotic pump tablets.</p><p><b>METHOD</b>HPLC was adopted for determination, with Shimadzu's ODS-SP column (4.6 mm x 150 mm, 5 microm), flow rate of 1 mL x min(-1), and column temperature of 30 degrees C. Protein in plasma samples of tanshinone II(A) and salvianolic acid B was removed by ethyl acetate extract and acetone precipitation method respectively. Their pharmacokinetic parameters were calculated based on determination results.</p><p><b>RESULT</b>The methodology study on the two constituents with different polarity showed conformity to the requirements. Compared with conventional Danshen tablets, Danshen multi-component osmotic pump tablets showed decrease in Cmax and extension in Tmax after oral administration in Beagle dogs.</p><p><b>CONCLUSION</b>Danshen multi-component osmotic pump tablet has a good sustained-release effect compared with conventional Danshen tablets.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osmosis
/
Tablets
/
Time Factors
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Chemistry
/
Salvia miltiorrhiza
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS