Tissue distribution of ginsenoside Rg1 before and after modification by PEG / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate targeted distribution of ginsenoside Rg1 in mice tissues before and after modification by the PEG.</p><p><b>METHOD</b>SD mice were randomly divided into two groups and given Rg1 and PEG-Rg1 by intravenous injection respectively. Their samples of blood and organ tissues were taken at different time points. The content of Rg1 in samples were determined by UPLC and used as indicator to observe the targeted distribution of Rg1 in mice tissues.</p><p><b>RESULT</b>The AUC of ginsenoside Rg1 in tissues of the Rg1 group were in the order of liver, kidney, lung, heart and spleen, with the liver targeting coefficient was of 2.01. While the AUC of ginsenoside Rg1 in tissues of the PEG-modified group were in the order of the kidney, liver, lung, heart, spleen, with the liver targeting coefficient was of 9.21.</p><p><b>CONCLUSION</b>PEG modified Rg1 can increase Rg1's targeting selectivity to the liver, kidney and lung in mice.</p>