Effect and mechanism of traditional Chinese medicine and their active constituents in postmenopausal osteoporosis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1693-1699, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-338779
ABSTRACT
Postmenopausal osteoporosis is one of the commonest systemic bone metabolism diseases among menopausal women, mainly caused by lowering internal estrogen. Although Hormone Replacement Therapy (HRT) is an effective method in clinical practice for years, it shows side-effect in increasing gynecological carcinoma. It has already been proved by clinical tests that multiple traditional Chinese medicine formulas and their monomer ingredients and phytoestrogen-like active constituents contained in traditional Chinese medicines are effective on treating osteoporosis with relatively less side-effects comparing with HRT. They show protective and therapeutic effects by acting on estrogen receptors of targeted tissues and targeted cells and then affecting expressions of bone metabolism-related regulatory proteins and factors in downstream signal conduct paths. Recent studies on estrogen related receptor (ERR) provide new possibilities and pathways for mechanism of traditional Chinese medicine and their active constituents in osteoporosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Receptors, Estrogen
/
Osteoporosis, Postmenopausal
/
Chemistry
/
Chemistry, Pharmaceutical
/
Therapeutic Uses
/
Drug Therapy
/
Medicine, Chinese Traditional
/
Metabolism
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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