Dose-effect relationship between premature chromosome and irradiation dose / 中华劳动卫生职业病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the dose-effect relationship between premature chromosome condensation induced by Calyculin A and irradiation dose.</p><p><b>METHODS</b>The human peripheral blood was irradiated by (137)Cs gamma radial. The irradiation dose included 0, 0.5, 1.0, 2.0, 3.0, 4.0, 5.0 Gy. The premature chromosome condensation induced by Calyculin A was observed, and dyed by centromeric banding.</p><p><b>RESULTS</b>There was the quadratic relation between the total aberration, fragment, dicentric+centric ring (dic+r) ration and irradiation dose.</p><p><b>CONCLUSION</b>Premature chromosome condensation induced by Calyculin A can be used as a biodosimetry.</p>