Correlation between T lymphoma invasion and metastasis 1 expression and epithelial-mesenchymal transition in human colorectal carcinomas / 南方医科大学学报
Journal of Southern Medical University
; (12): 232-235, 2009.
Article
in Zh
| WPRIM
| ID: wpr-339023
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between T lymphoma invasion and metastasis 1 (Tiam1) and epithelial-mesenchymal transition (EMT) in human colorectal carcinomas.</p><p><b>METHODS</b>Tiam1, E-cadherin, CK, and vimentin expressions in normal colorectal epithelium, colorectal carcinomas (CRC) and CRC with lymphatic metastasis were determined by immunohistochemistry using a two-step method.</p><p><b>RESULTS</b>Tiam1 expression was significantly higher in CRC than in normal colorectal epithelium (P<0.01) in close correlation to the degree of tumor differentiation (P<0.05). Higher Tiam1 expression was detected in CRC with lymphatic metastasis than in primary CRC (P<0.05). The expressions of E-cadherin and CK in CRC tissues were significantly lowered in comparison with those in normal colorectal epithelium (P<0.01), showing a correlation to tumor differentiation (P<0.01) but not to lymphatic metastasis. Vimentin was significantly overexpressed in CRC (P<0.01) and correlated to tumor differentiation (P<0.01) but not to lymphatic metastasis. Tiam1 expression was inversely correlated to E-cadherin and CK, but positively to vimentin.</p><p><b>CONCLUSION</b>Tiam1 is related to the metastasis of colorectal carcinoma, and may induce EMT to promote CRC metastasis.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Physiology
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Colorectal Neoplasms
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Adenocarcinoma
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Cadherins
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Cell Movement
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Guanine Nucleotide Exchange Factors
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Epithelial Cells
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Cell Transdifferentiation
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T-Lymphoma Invasion and Metastasis-inducing Protein 1
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article