Seroprevalence and diagnostic value of aquaporin-4 antibody in patients with inflammatory central nervous system demyelinating diseases / 南方医科大学学报
Journal of Southern Medical University
; (12): 350-352, 2011.
Article
in Zh
| WPRIM
| ID: wpr-339036
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess the seroprevalence and diagnostic value of aquaporin-4 antibody (AQP4-Ab) in patients with inflammatory central nervous system demyelinating diseases.</p><p><b>METHODS</b>Seventy-two patients with neuromyelitis optica (NMO), 68 with multiple sclerosis (MS), 4 with optic neuritis (ON), and 41 with transverse myelitis (TM) were included in this study. The TM group comprised 19 patients with non-longitudinally extensive transverse myelitis (nLETM), 14 with monophasic longitudinally extensive transverse myelitis (mLETM), and 8 with recurrent longitudinally extensive transverse myelitis (rLETM). The serum levels of AQP4-Ab was detected by indirect immunofluorence assay in these patients.</p><p><b>RESULTS</b>AQP4-Ab was detected in 72.2% (52/72) patients with NMO, 5.9% (4/68) patients with MS, 25.0% (1/4) patients with ON, and 17.1% (7/41) patients with TM, showing a significant difference in the positivity between NMO and MS groups (P<0.01). AQP4-Ab seropositivity rate was 5.3% (1/19) in nLETM patients, 62.5% (5/8) in rLETM patients and 7.1% (1/14) in mLETM patients, significantly higher in rLETM than in nLETM (P<0.01) and mLETM groups (P<0.05), but no statistical difference was found between rLETM and NMO groups.</p><p><b>CONCLUSIONS</b>A high seroprevalence of AQP4-Ab is observed in patients with NMO and rLETM, which support the hypothesis that NMO and rLETM belong to NMO spectrum disorders. AQP4-Ab can serve as a useful index for diagnosing NMO and differential diagnosis from MS. More attention and effective immunosuppressive treatments should be given to patients positive for AQP4-Ab.</p>
Full text:
1
Index:
WPRIM
Main subject:
Autoantibodies
/
Blood
/
Seroepidemiologic Studies
/
Neuromyelitis Optica
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Demyelinating Autoimmune Diseases, CNS
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Diagnosis
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Allergy and Immunology
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Aquaporin 4
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Multiple Sclerosis
Type of study:
Diagnostic_studies
Limits:
Female
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Humans
/
Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article