Role of CD4+CD25+Foxp3+ regulatory T cells in type 2 diabetic nephropathy / 南方医科大学学报
Journal of Southern Medical University
; (12): 137-139, 2009.
Article
in Zh
| WPRIM
| ID: wpr-339045
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in type 2 diabetic nephropathy and provide new clues for prevention and treatment of type 2 diabetic nephropathy.</p><p><b>METHODS</b>Flow cytometry was used to analyze the expression rate of CD4+CD25+Foxp3+ Treg cells in 60 patients with type 2 diabetes and 15 normal subjects.</p><p><b>RESULTS</b>No significant difference was found in the expression rate of CD4+CD25+Foxp3+ Treg cells between the control group and the type 2 diabetic patients. In the type 2 diabetic patients with microalbuminuria and macroalbuminuria, the expression of CD4+CD25+Foxp3+ Treg cells was significantly lowered in comparison with that in the control group (P<0.05), and patients with macroalbuminuria showed significantly lower expression of CD4+CD25+Foxp3+ Treg cells than the microalbuminuric patinets (P<0.05). Significant inverse correlations were noted between the disease course and the expression of CD4+CD25+Foxp3+ Treg cells and between the urinary albumin excretion rate (UAER) and the expression of CD4+CD25+Foxp3+ Treg cells.</p><p><b>CONCLUSION</b>CD4+CD25+Foxp3+ Treg cells may play a role in the occurrence and development of type 2 diabetic nephropathy.</p>
Full text:
1
Index:
WPRIM
Main subject:
CD4 Antigens
/
Case-Control Studies
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T-Lymphocyte Subsets
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T-Lymphocytes, Regulatory
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Diabetes Mellitus, Type 2
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Diabetic Nephropathies
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Allergy and Immunology
/
Forkhead Transcription Factors
/
Interleukin-2 Receptor alpha Subunit
/
Flow Cytometry
Type of study:
Observational_studies
Limits:
Adult
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Aged
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Female
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Humans
/
Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article