Expression of heparin-binding epidermal growth factor-like growth factor in patients with gastric carcinoma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 44-46, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-339070
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in patients with gastric carcinoma in different stages.</p><p><b>METHODS</b>The expressions of HB-EGF protein and mRNA in normal gastric tissues, metaplasic intestinal mucosa, early-stage gastric cancer and advanced-stage gastric cancer tissues were detected by immunohistochemistry and in situ hybridization.</p><p><b>RESULTS</b>HB-EGF expression was only detected in the parietal cells of the gastric fundic glands and in gastrin cells of the pyloric glands in normal gastric tissues. Weak HB-EGF expression was detected in the epithelial cells of the gastric mucosa in intestinal metaplasic mucosa, and the expression increased in all layers of the gastric mucosa in early-stage gastric cancer. Intense HB-EGF expression was observed in advanced gastric cancer.</p><p><b>CONCLUSION</b>Increased HB-EGF expression may be implicated in the pathogenesis and development of gastric carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
RNA, Messenger
/
Tumor Cells, Cultured
/
Adenocarcinoma
/
Intercellular Signaling Peptides and Proteins
/
Heparin-binding EGF-like Growth Factor
/
Gastric Mucosa
/
Genetics
/
Metabolism
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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