Therapeutic effect of taxol combined with cisplatin for pulmonary metastasis from breast cancer / 中国肺癌杂志

ABSTRACT

<p><b>BACKGROUND</b>Breast cancer is one of the most common malignant tumors in women. Lung metastasis occurs in 12-18 percent of patients within 5 years after operation. For those with pulmonary metastasis from breast cancer, chemotherapy is still considered the best choice. The aim of this study is to explore the clinical therapeutic and adverse effects of taxol combined with cisplatin (TP) for pulmonary metastasis from breast cancer.</p><p><b>METHODS</b>Twenty-two cases of clinically confirmed pulmonary metastasis from breast cancer were treated with taxol (175mg/m² twice daily on days 1-3) and cisplatin (20mg/m² on days 2-4) for 4 cycles, with 21 days as one cycle.</p><p><b>RESULTS</b>There were 3 cases with complete response, 10 with partial response, 5 with stable disease and 4 with progressive disease. Myelosuppression and gastrointestinal reactions were the main adverse effects.</p><p><b>CONCLUSIONS</b>The combination of taxol and cisplatin is effective and safe for pulmonary metastasis from breast cancer.</p>