Your browser doesn't support javascript.
loading
A randomized clinical trial of Uroacitides combined with NP and NP regimen alone for advanced non-small cell lung cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 536-539, 2006.
Article in Chinese | WPRIM | ID: wpr-339345
ABSTRACT
<p><b>BACKGROUND</b>Uroacitides is a group of cell differentiation inducers, which is purified from fresh human urine. Preclinical studies of Uroacitides have showed that cancer cells could be induced to differentiate, and the growth of cancer cells could be inhibited by Uroacitides. The aim of this study is to compare the efficacy and toxicity between Uroacitides combined with NP regimen and NP alone in treatment of advanced non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>Forty-two cases of advanced NSCLC were randomized into Uroacitides+NP and NP groups. NP group NVB 25mg/m² on days 1 and 8, DDP 75mg/m² on day 1. Uroacitides combined with NP group Uroacitides of 300mL was given through subclavian catheter daily for 7 days prior to the NP chemotherapy, then concurrently with NP regimen for 2 cycles, except the days of administration of chemotherapy.</p><p><b>RESULTS</b>In the Uroacitides+NP group, the overall response rate was 44.4%, and 20.0% in the NP group (P > 0.05). The median survival time was 9 months in the Uroacitides+NP group and 6 months in the NP group (P=0.0287). The main toxicities were myelosuppression, gastrointestinal reaction and alopecia, and there was no significant difference in incidences of toxicities between the two groups (P > 0.05).</p><p><b>CONCLUSIONS</b>Uroacitides combined with NP regimen shows a good curative effect and low toxicity, and may significantly prolong the median survival time for advanced NSCLC.</p>
Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2006 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2006 Type: Article