Influence of estradiol benzoate on fluid reabsorption capacity of rat efferent ductuli / 中华男科学杂志
National Journal of Andrology
;
(12): 806-809, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-339421
ABSTRACT
<p><b>OBJECTIVE</b>To study the influence of estradiol benzoate (E2B) on the fluid reabsorption capacity of rat efferent ductuli.</p><p><b>METHODS</b>Newborn male Sprague-Dawley rats were injected subcutaneously with E2B (0.2 mg/5 g body weight), and the histological morphology of efferent ductulus, epithelial ultrastructure, and immunoexpression of AQP-1 were investigated on postnatal day 14, 21, 28, 42 and 56, respectively. Vehicle was given to the controls.</p><p><b>RESULTS</b>After exposure to E2B, the lumina of the efferent ductuli dilated greatly (P < 0.05), and the epithelium height decreased significantly (P < 0.01), microvilli of nonciliated cells short and sparse, endocytic apparatus implicated in fluid reabsorption scarce, and with no AQP-1 expression.</p><p><b>CONCLUSION</b>High dosage of E2 B neonatally administrated to rats damages the fluid reabsorption capacity of efferent ductuli.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Testis
/
Body Fluids
/
Rats, Sprague-Dawley
/
Absorption
/
Epithelial Cells
/
Estradiol
/
Aquaporin 1
/
Toxicity
/
Animals, Newborn
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2005
Type:
Article
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