Polymorphism profile of nine short tandem repeat Loci in the Han chinese / 基因组蛋白质组与生物信息学报·英文版
Genomics, Proteomics & Bioinformatics
;
(4): 166-170, 2003.
Article
in English
| WPRIM
| ID: wpr-339511
ABSTRACT
Nine short tandem repeat (STR) markers (D3S1358, VWA, FGA, THO1, TPOX, CSFIPO, D5S818, D13S317, and D7S820) and a sex-identification marker (Amelogenin locus) were amplified with multiplex PCR and were genotyped with a four-color fluorescence method in samples from 174 unrelated Han individuals in North China. The allele frequencies, genotype frequencies, heterozygosity, probability of discrimination powers, probability of paternity exclusion and Hardy-Weinberg equilibrium expectations were determined. The results demonstrated that the genotypes at all these STR loci in Han population conform to Hardy-Weinberg equilibrium expectations. The combined discrimination power (DP) was 1.05 x 10(-10) within nine STR loci analyzed and the probability of paternity exclusion (EPP) was 0.9998. The results indicate that these nine STR loci and the Amelogenin locus are useful markers for human identification, paternity and maternity testing and sex determination in forensic sciences.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Sex Determination Analysis
/
Ethnicity
/
China
/
Polymerase Chain Reaction
/
Tandem Repeat Sequences
/
Dental Enamel Proteins
/
Electrophoresis
/
Amelogenin
/
Forensic Medicine
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Genomics, Proteomics & Bioinformatics
Year:
2003
Type:
Article
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