Expression of c-kit and Cx43 in neonates with spontaneous gastric perforation / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 787-789, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-339531
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical significance of interstitial cell of Cajal (ICC) in spontaneous neonatal gastric perforation by examining the expression of c-kit and Cx43 in neonates with this disorder.</p><p><b>METHODS</b>The gastric specimens of 19 cases of neonatal gastric perforation from 2001 to 2010 and 8 cases of accidental death without digestive tract malformations (control) were collected. Immunohistochemical staining was employed to examine the expression of c-kit and Cx43 (immunomarkers of ICCs) in gastric tissues.</p><p><b>RESULTS</b>The muscular layer of the stomach wall became thinner or deficient in the gastric perforation group. C-kit and Cx43 positive cells in gastric tissues decreased significantly in the gastric perforation group compared with those in the control group (P<0.01).</p><p><b>CONCLUSIONS</b>The development of spontaneous neonatal gastric perforation is associated with the decreased quantity of ICCs and damaged gap junction structure of the stomach wall.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Rupture, Spontaneous
/
Stomach
/
Stomach Rupture
/
Chemistry
/
Connexin 43
/
Proto-Oncogene Proteins c-kit
/
Interstitial Cells of Cajal
/
Metabolism
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article
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