Effects of valproate sodium on pituitary gonadotropin in adolescent girls with epilepsy / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 725-727, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-339548
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of valproate sodium (VPA) on the level and axle of pituitary gonadotropin in adolescent girls with epilepsy.</p><p><b>METHODS</b>Twenty-three adolescent girls with epilepsy aged from 8 to 14 years were treated with VPA for 1 year. The levels of serum pituitary gonadotropin including estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin and testosterone were measured before treatment and 3 months, 6 months and 1 year after treatment.</p><p><b>RESULTS</b>The serum levels of estradiol, follicle-stimulating hormone, luteinizing hormone and prolactin in the children with epilepsy were not significantly different during the 1 year VPA treatment compared with pretreatment. However, the serum level of testosterone was reduced 1 year after treatment (0.4±0.3 ng/mL) compared with pretreatment (0.7±0.4 ng/mL) and 3 months after treatment (0.7±0.4 ng/mL) (P<0.05).</p><p><b>CONCLUSIONS</b>VPA treatment for 1 year does not increase serum levels of androgen in adolescent girls with epilepsy, suggesting that VPA is an ideal choice of treatment for the girls.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Valproic Acid
/
Therapeutic Uses
/
Drug Therapy
/
Epilepsy
/
Gonadotropins, Pituitary
/
Anticonvulsants
Limits:
Adolescent
/
Child
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article
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