Effects of bifidobacteria on respiratory and gastrointestinal tracts in neonates receiving mechanical ventilation / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 704-707, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-339554
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of bifidobacterium on respiratory and gastrointestinal tracts in neonates receiving mechanical ventilation.</p><p><b>METHODS</b>The eligible neonates were randomly assigned into two groups observed (n=38) and control (n=43). The observed group was given bifidobacteria daily (one capsule per time, for 7 days) by nasal feeding from the next day after mechanical ventilation. Gastric pH, gastric bacteria colonization, feeding intolerance, weight gain, the incidence of ventilator-associated pneumonia (VAP), and the homology between the bacteria isolated from intra-gastric colonization with those causing VAP were observed.</p><p><b>RESULTS</b>The incidence of gastric pH≤3 in the observed group was significantly higher than that in the control group 3, 5 and 7 days after mechanical ventilation (P<0.01). The rate of gastric bacteria colonization in the observed group was significantly lower than that in the control group 5 and 7 days after mechanical ventilation (P<0.01). The incidences of feeding intolerance and VAP in the observed group were significantly lower than those in the control group (P<0.05, P<0.01, respectively). The rate of homology of the bacteria isolated from intra-gastric colonization with those causing VAP in the observed group was significantly lower than that in the control group (P<0.01). There were no significant differences in the weight gain between the two groups.</p><p><b>CONCLUSIONS</b>Bifidobacterium can decrease gastric pH, gastric bacteria colonization and feeding intolerance, thus blocks the infection route "stomach-oropharynx-respiratory tract" indirectly and decreases the incidence of endogenous VAP in neonates receiving mechanical ventilation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Respiration, Artificial
/
Bifidobacterium
/
Weight Gain
/
Epidemiology
/
Gastrointestinal Tract
/
Pneumonia, Ventilator-Associated
/
Gastric Acidity Determination
/
Microbiology
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article
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