Efficacy of thalidomide for treatment of juvenile idiopathic arthritis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 631-634, 2011.
Article
in Zh
| WPRIM
| ID: wpr-339575
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of thalidomide in the treatment of juvenile idiopathic arthritis (JIA).</p><p><b>METHODS</b>Twelve children with JIA who did not respond to conventional treatment were administered with thalidomide (2 mg/kg daily). The symptoms, signs, and laboratory test results were compared before and after treatment. The thalidomide-related side effects were observed.</p><p><b>RESULTS</b>The average dosage of prednisone was reduced from 1.92 ± 0.16 mg/kg•d to 0.49 ± 0.42 mg/kg•d in the 12 patients 6 months after thalidomide treatment (P<0.01). Four patients did not need prednisone treatment any more. White blood cell count, erythrocyte sedimentation rate (ESR), C reactive protein (CRP) and serum ferritin (SF) significantly decreased after treatment in all of 12 patients (P<0.01). Hemoglobin level increased to normal in 8 patients after treatment (P<0.01). The number of affected joints decreased from 5 before treatment to zero to 2 after treatment in patients with polyarticular JIA (P<0.01). Signs of hip involvement and Schober's sign turned negative in enthesitis-related cases. No thalidomide-related side effects were observed.</p><p><b>CONCLUSIONS</b>Thalidomide is effective in the treatment of JIA in children who do not respond to conventional treatment.</p>
Full text:
1
Index:
WPRIM
Main subject:
Arthritis, Juvenile
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Thalidomide
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Blood
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Prednisone
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Retrospective Studies
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Therapeutic Uses
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Drug Therapy
Type of study:
Observational_studies
Limits:
Adolescent
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Child
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article