Serum levels of 25-(OH)D(3) and total IgE in children with asthma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 551-553, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-339597
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes and clinical significance of serum levels of 25-(OH)D(3) and total IgE in children with asthma.</p><p><b>METHODS</b>Thirty children with asthma, 40 children with asthmatic bronchitis, and 40 healthy children were enrolled. Double-antibody radioimmunoassay was used to detect the levels of serum 25-(OH)D(3) and total IgE.</p><p><b>RESULTS</b>Serum 25-(OH)D(3) levels (18±3 ng/Ml)decreased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (43±3 ng/mL) and the control group (43±3 ng/mL) (P<0.01). In contrast, serum total IgE levels (192±16 IU/mL) increased significantly in the asthmatic group compared with those in the asthmatic bronchitis group (123±14 IU/mL) and the control group (118±15 IU/mL) (P<0.01). Serum 25-(OH)D(3) levels were negatively correlated with serum total IgE levels in asthmatic children (r=-0.783, P<0.01). There were no correlation between serum 25-(OH)D(3) levels and serum total IgE level in the asthmatic bronchitis and the control groups.</p><p><b>CONCLUSIONS</b>25-(OH)D(3) may play an important role in the pathogenesis of asthma. The increased serum 25-(OH)D(3) level may inhibit total IgE expression, suggesting that increasing serum 25-(OH)D(3) level might be a new option for the prevention and treatment of asthma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Blood
/
Calcifediol
/
Immunoglobulin E
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS