The effect of restrained stress on cardiac myocyte apoptosis in rats and Chinese herbs yixinning interference on it / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 117-120, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-339664
ABSTRACT
<p><b>AIM</b>To discuss the effects of restrained stress on cardiac myocyte apoptosis of rats in the whole body, and the effect of anti-stress-induced cardiac myocyte injury treated by Chinese herbs yixinning.</p><p><b>METHODS</b>Agarose gel electrophoresis and TUNEL are used to detect cardiac myocyte apoptosis.</p><p><b>RESULTS</b>(1) When restrained stress 1,2,4 week, the DNA ladder of stress groups was negative, while in situ apoptosis of stress groups increased apparently compared with control group (P < 0.01). (3) The DNA ladder of yixinning groups was negative too, while in situ apoptosis of yixinning groups decreased compared with stress group (P < 0.05). (3) Whereas in distilled water group, the above indices had no statistical significance compared with stress model group (P > 0.05).</p><p><b>CONCLUSION</b>The restrained stress can induce cardiac myocyte apoptosis in rats. Chinese herbs "yixnning" can inhibit cardiac myocyte apoptosis, and have functions of anti-stress injury.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Stress, Physiological
/
Restraint, Physical
/
Drugs, Chinese Herbal
/
Rats, Wistar
/
Apoptosis
/
Myocytes, Cardiac
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2003
Type:
Article
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