Inducible nitric oxide synthase induces beta-amyloid neurotoxicity in vivo / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 329-332, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-339726
ABSTRACT
<p><b>AIM</b>To investigate the causative role of nitric oxide synthase (NOS) and nitric oxide (NO) in neurotoxicity of beta-amyloid (Abeta) and the pathogenesis of Alzheimer's disease (AD).</p><p><b>METHODS</b>Using behavioral and neuropathological methods, we observed the effects of Abeta(1-40) injection into hippocampi on rats learning and memory in Y maze and on the neuropathology in hippocampi. The intervention by intraperitoneal administration of aminoguanidine (AG), a selective inducible NOS (iNOS) inhibitor, and 7-nitroindazole (7-NI), a selective neuronal NOS (nNOS) inhibitor, in the neurotoxicity of Abeta(1-40) was studied then.</p><p><b>RESULTS</b>The capability of acquisition and retrieval in Y maze and local neurons in hippocampus of the rats were impaired significantly after Abeta(1-40) injection. Intraperitoneal administration of AG, but not 7-NI, could prevent the damages caused by Abeta(1-40) injection above-mentioned.</p><p><b>CONCLUSION</b>iNOS/NO participates in the mechanisms of Abeta-induced neurotoxicity and may play an important role in the pathogenesis of AD.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Amyloid beta-Peptides
/
Rats, Sprague-Dawley
/
Maze Learning
/
Nitric Oxide Synthase
/
Nitric Oxide Synthase Type II
/
Toxicity
/
Alzheimer Disease
/
Guanidines
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2002
Type:
Article
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