Research progress in the structure and fuction of Orthopoxvirus host range genes

Zheng LIU; Ying LIU; Yi-Ming SHAO

Research progress in the structure and fuction of Orthopoxvirus host range genes / 病毒学报

Zheng LIU; Ying LIU; Yi-Ming SHAO.

Chinese Journal of Virology ; (6): 437-441, 2013.

Article in Chinese | WPRIM | ID: wpr-339931

ABSTRACT

ABSTRACT

Orthopoxvirus vector has a broad prospect in recombinant vaccine research, but the rarely severe side-effect impedes its development. Vaccinia virus and Cowpox virus of Orthopoxvirus have broad host range, and they have typical host range genes as K1L, CP77 and C7L. These three genes affect host range of Vaccinia virus, disturb the cell signaling pathways, suppress immune response and are related to virulence.

Subject(s)

Cell Line; Cowpox virus; Genetics; Allergy and Immunology; Virulence; Physiology; Genetic Vectors; Host Specificity; Genetics; Orthopoxvirus; Genetics; Allergy and Immunology; Virulence; Physiology; Signal Transduction; Vaccines, Synthetic; Allergy and Immunology; Vaccinia virus; Genetics; Allergy and Immunology; Virulence; Physiology; Viral Proteins; Genetics; Metabolism; Viral Vaccines; Allergy and Immunology; Virulence

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Vaccinia virus / Viral Proteins / Virulence / Viral Vaccines / Vaccines, Synthetic / Signal Transduction / Cowpox virus / Cell Line / Orthopoxvirus Language: Chinese Journal: Chinese Journal of Virology Year: 2013 Type: Article

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