The antagonism of rhizoma gastrodiae to lead-induced damage of hippocampus in rats / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 331-333, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-340073
ABSTRACT
<p><b>OBJECTIVE</b>To observe and explore the antagonism of rhizoma gastrodiae (RGT) to the impairment of learning and memory ability induced by lead in rats.</p><p><b>METHODS</b>36 Wistar rats were randomly divided into 3 groups, 12 rats in every group, (1) control group treated with distilled water; (2) lead group treated with lead acetate (0.1 g.kg-1.d-1); (3) lead-RGT group lead acetate (0.1 g.kg-1.d-1) + RGT(4.0 g.kg-1.d-1). The ability of learning and memory of the rats was measured monthly by swimming test; 3 months later, the rats were decapitated and nitric oxide(NO) and total antioxidative capacity(TAOC) in hippocampus were measured immediately and the examination for pathology was also made.</p><p><b>RESULTS</b>(1) In swimming test, the number of seeking for anchorage in lead group(1, 2, 3 month 10.10 +/- 1.10, 7.80 +/- 1.32, 5.40 +/- 0.97 respectively) were significantly decreased, compared with the control(P < 0.01); the number of seeking for anchorage in RGT-lead group(1, 2, 3 month 11.90 +/- 0.95, 10.90 +/- 0.95, 9.70 +/- 0.96 respectively) were significantly increased, compared with lead group(P < 0.01). (2) NO (0.733 +/- 0.015) mumol/g pro and TAOC (0.945 +/- 0.017) U/mg pro in hippocampus of lead group were significantly decreased compared with the control(P < 0.01) whereas NO(0.769 +/- 0.021) mumol/g pro and TAOC(0.986 +/- 0.010) U/mg pro in hippocampus of RGT-lead group were significantly increased compared with lead group(P < 0.01). (3) Pathological examination showed that in lead group, marked atrophy in hippocampus, cellular denaturation and necrosis, dissolution and disappearance in axon were found. In lead-RGT group, the atrophy of hippocampus was not obvious, the cell morphology was nearly normal, no obvious abnormal changes were seen.</p><p><b>CONCLUSION</b>RGT is antagonistic to the impairment of hippocampus and of learning and memory ability induced by lead.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Swimming
/
Drugs, Chinese Herbal
/
Rats, Wistar
/
Toxicity
/
Hippocampus
/
Lead
/
Learning
/
Memory
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2002
Type:
Article
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