The relationship between silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 93-96, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-340117
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relation between the susceptibility to silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes in Chinese Hans.</p><p><b>METHODS</b>HLA-DRB1 * and DQB1 * gene polymorphism were tested in 48 silicosis patients and 100 normal controls by using polymerase chain reaction of sequence-specific primers (PCR-SSP).</p><p><b>RESULTS</b>The allele frequencies of DRB1 * 1401 and DQB1 * 05 in silicosis patients were significantly higher than those in normal controls (chi 2 = 5.61, P = 0.0066, RR = 17.40; chi 2 = 10.70, P = 0.0011, RR = 3.81, respectively), while the allele frequency of DRB1 * 09 was significantly lower in silicosis patients than that in controls (chi 2 = 5.70, P = 0.0187, RR = 0.21). There was a significant difference between the patient group and control group.</p><p><b>CONCLUSION</b>HLA-DRB1 * 1401 and DQB1 * 05 may be the susceptible genes and HLA-DRB1 * 09 the protection gene of silicosis, both susceptibility and protection may be related to HLA-DR gene locus. The joint action of allele genes may affect the pathogenesis of silicosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Silicosis
/
HLA-DQ Antigens
/
HLA-DR Antigens
/
Polymerase Chain Reaction
/
Genetic Predisposition to Disease
/
HLA-DQ beta-Chains
/
HLA-DRB1 Chains
/
Gene Frequency
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2002
Type:
Article
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