Effects of yikunning on the expressions of bcl-2 and bax in rat ovaries during perimenopausal period / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 177-180, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-340202
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Yikunning (YKN, Chinese Traditional Medicine) on the expressions of bcl-2 and bax in rat ovaries during perimenopausal period.</p><p><b>METHODS</b>Thirty female Wistar rats during perimenopausal period were selected by unforced aging. Then the rats were divided into 3 groups randomly YKN group, Livial control group and Aged control group. Ten young female Wistar rats were selected as young control group. Intragastric administrations were conducted for 4 weeks once daily continuously. The expressions of Bcl-2 Bax mRNAs and proteins in rat ovaries were detected by RT-PCR and Western blot.</p><p><b>RESULTS</b>The levels of Bcl-2, Bax mRNAs and proteins in rat ovaries in YKN group were higher than those in Aged control group, which showed differences among them (P < 0.01). The Bcl-2/Bax mRNA rate and protein rate in rat ovaries in YKN group were higher than those in Aged control group, which showed differences among them (P < 0.05 or P < 0.01).</p><p><b>CONCLUSION</b>YKN could increase the expressions of Bcl-2, Bax mRNAs and proteins and up-regulate the Bcl-2/Bax mRNA rate, protein rate in rat ovaries during perimenopausal period, which might be one of the molecular mechanisms of YKN postponed the ovarian failure and cured perimenopausal syndrome.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovary
/
Pharmacology
/
Physiology
/
RNA, Messenger
/
Drugs, Chinese Herbal
/
Up-Regulation
/
Rats, Wistar
/
Proto-Oncogene Proteins c-bcl-2
/
Perimenopause
/
Bcl-2-Associated X Protein
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2010
Type:
Article
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