Effect of Ligusticum and its two main components on muscle atrophy in a hind limb unloaded rat model / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 109-113, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-340221
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Ligusticum and its two components (Sodium Ferulate and Ligustrazine as main efficacy components in Ligusticum for invigorating blood circulation) on muscle atrophy in a hind limb unloaded rat model.</p><p><b>METHODS</b>The tail-suspended rats were subjected to a 14-days disuse, immunohistochemistry and hemorheology were used to study the effects of medicines on soleus muscle.</p><p><b>RESULTS</b>Compared with HLU+ W (1) The CSA of soleus type I fibers in HLU + SfH and HLU+ TmpH increased by 37.3% and 39.4% respectively (P < 0.05). (2) Expression level of MHC II were inhibited in all treatment groups (P < 0.01). (3) Expression of MHC II in nuclear bag 2 fiber were altered from positive to negative. (4) The blood viscosity in low shear rates decreased obviously (P < 0.01), even near to control.</p><p><b>CONCLUSION</b>Ligusticum and its two main efficacy components (Sodium Ferulate and Ligustrazine) can prevent soleus atrophy induced by disuse, and Sodium Ferulate and Ligustrazine in high dose showed most efficacy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pyrazines
/
Blood
/
Drugs, Chinese Herbal
/
Muscular Atrophy
/
Random Allocation
/
Chemistry
/
Rats, Sprague-Dawley
/
Hemorheology
/
Muscle Fibers, Skeletal
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2010
Type:
Article
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