Effect of decitabine on immune regulation in patients with acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1448-1452, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-340481
ABSTRACT
Based on the representative articles in recent years, the different mechanisms of decitabine on immune regulation in patients with acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT) are summarized. Decitabine improves the expression of WT1 gene to stimulate specific cytotoxic T cells which can enhance graft versus leukemia effect (GVL) and improve the expression of FOXP3 gene to stimulate regulatory T cells so as to inhibit the acute graft versus host disease (GVHD). Through the above-mentimed mechanisms, decitabine can improve both therapeutic effect and quality of life in the patients with AML after allogeneic HSCT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Quality of Life
/
Azacitidine
/
Therapeutics
/
Transplantation, Homologous
/
T-Lymphocytes, Cytotoxic
/
Leukemia, Myeloid, Acute
/
T-Lymphocytes, Regulatory
/
Hematopoietic Stem Cell Transplantation
/
Graft vs Leukemia Effect
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS