Effect of advanced maternal age on birth defects and postnatal complications of neonates / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1084-1089, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-340562
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of advanced maternal age on birth defects and postnatal complications of neonates.</p><p><b>METHODS</b>Among the 1 109 neonates who were born at The First People's Hospital of Yunnan Province between January 2014 and December 2015, 536 neonates whose mothers were aged ≥35 years were enrolled as advanced age group and 573 neonates whose mothers were aged <35 years were enrolled as appropriate-age group. The incidences of the comorbidities in pregnancy, fetal intrauterine distress, neonatal birth defects, and postnatal complications were compared between the two groups. A univariate logistic regression analysis was performed to analyze the effect of advanced maternal age on neonatal comorbidities during perinatal period.</p><p><b>RESULTS</b>Compared with the appropriate-age group, the advanced age group had significantly higher rate of caesarean section and incidence rates of multiple birth, gestational diabetes, pregnancy-induced hypertension, in vitro fertilization, and fetal intrauterine distress (P<0.01). The neonates in the advanced age group had a significantly higher incidence rate of cleft lip and palate and a significantly lower rate of skeletal dysplasia than in the appropriate-age group (P<0.05). Advanced maternal age was the risk factor for fetal intrauterine distress (OR=2.27, 95%CI 1.33-3.88, P=0.003), neonatal resuscitation (OR=1.66, 95%CI 1.19-2.31, P=0.003), and intracranial hemorrhage (OR=2.70, 95%CI 1.21-6.04, P=0.02).</p><p><b>CONCLUSIONS</b>The women of maternal advanced age have higher incidence rates of pregnancy comorbidities than those of appropriate age, and the neonates born to the mothers of advanced maternal age have a higher incidence rate of cleft lip and palate. Advanced maternal age may increase the risks of fetal intrauterine distress, neonatal resuscitation, and intracranial hemorrhage.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy Complications
/
Congenital Abnormalities
/
Logistic Models
/
Cerebral Hemorrhage
/
Cesarean Section
/
Maternal Age
/
Infant, Newborn, Diseases
Type of study:
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Type:
Article
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