Neuregulin-1 temperature-dependently inhibits the long-term potentiation in the CA1 region in mouse hippocampal slices / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1771-1774, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-340731
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of neurogulin-1 (NRG1) on the transmission and plasticity of CA1 synapses in mouse hippocampal slices at different temperatures.</p><p><b>METHODS</b>Under room temperature (26-/+1 degrees C) or physiological temperature (32-/+1 degrees C), field excitatory postsynaptic potential (fEPSP) evoked by extracellular microelectrode recording technique was recorded in the CA1 region in adult mouse hippocampal slices, and the long-term potentiation (LTP) was induced by high frequency stimulation (HFS). The effects of NRG1 on the baseline fEPSP and induction of LTP in CA1 region were observed.</p><p><b>RESULTS</b>No significant variation in the slope of fEPSP relative to the baseline fEPSP was observed after perfusion with NRG1 at room temperature or physiological temperature (P > 0.05). After HFS at the room temperature, the mean slope of fEPSP in the slices perfused with NRG1 was similar to that of the control group (P > 0.05), but HFS at the physiological temperature resulted in significant reduction in the mean slope of fEPSP in the slices perfused with NRG1 (P < 0.01).</p><p><b>CONCLUSION</b>NRG1 may temperature-dependently inhibit the induction of LTP in the CA1 region in mouse hippocampal slices.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Temperature
/
Long-Term Potentiation
/
Synaptic Transmission
/
Neuregulin-1
/
Hippocampus
/
Mice, Inbred C57BL
/
Neuronal Plasticity
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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