Establishment of a mouse model of biliary obstruction and its dynamic observations / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1579-1581, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-340775
ABSTRACT
<p><b>OBJECTIVE</b>To establish a mouse model of biliary obstruction.</p><p><b>METHODS</b>Sixty-four Balb/c mice were divided into experimental group and control group. Obstructive jaundice was induced in the mice in the experimental group by common bile duct ligation. The level of the common bile duct diameter, WBC, LYM MID, LYM%, MID% and ALT, AST, TBIL, DBIL, IBIL, ALP and CHOL were measured 12 h and 1, 2 ,3, 4, 5, and 7 days after the ligation. The morphological changes in the liver were also observed.</p><p><b>RESULTS</b>The level of common bile duct diameter, WBC, LYM, MID, LYM%, MID% and ALT, AST, TBIL, DBIL, ALP and CHOL all underwent changes with time following certain patterns.</p><p><b>CONCLUSION</b>The jaundice manifestation of this model is similar to that of patients with biliary obstruction, and this model may provide a reliable model for studying the mechanism of obstructive jaundice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
General Surgery
/
Cholestasis, Extrahepatic
/
Common Bile Duct
/
Disease Models, Animal
/
Ligation
/
Liver
/
Mice, Inbred BALB C
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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