Expression of MMP1 mRNA in oral squamous cell carcinoma and paired normal tissues / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1362-1364, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-340820
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mRNA expression of matrix metalloproteinase 1 (MMP1) gene in oral squamous cell carcinoma (OSCC) and the paired normal tissues.</p><p><b>METHODS</b>The differential expression of MMP1 mRNA between 30 OSCC and paired normal tissues were detected with reverse transcription-PCR (RT-PCR).</p><p><b>RESULTS</b>The relative expression level of MMP1 mRNA in the OSCC tissues showed a 3.26-fold increase in comparison with that in the paired normal tissues (4.06-/+0.52 vs 1.24-/+0.17, P<0.0001). In the 30 OSCC tissues, the relative expression level of MMP1 mRNA was higher in histological grade II/III tissues (4.31-/+0.68) than in grade I (3.87-/+0.57) tissues, higher in OSCC in advanced stages (III/IV) than in tumors in early stages (I/II) (4.18-/+0.67 vs 3.65-/+0.53), and also higher in OSCC with cervical lymph node invasion than in those without cervical lymph node invasion (4.32-/+0.71 vs 3.91-/+0.51), but these differences were not statistically significant (P>0.05).</p><p><b>CONCLUSION</b>MMP1 gene may play a role in local invasion of OSCC, and can serve as a potential biomarker molecule for diagnosis, treatment and prognostic evaluation of OSCC, with also clinical value for OSCC classification.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Gene Expression Regulation, Enzymologic
/
Gene Expression Regulation, Neoplastic
/
Reverse Transcriptase Polymerase Chain Reaction
/
Matrix Metalloproteinase 1
/
Genetics
/
Metabolism
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2008
Type:
Article
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