Immunosuppressive therapy after human lung transplantation / 中华外科杂志
Chinese Journal of Surgery
;
(12): 818-821, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-340910
ABSTRACT
<p><b>OBJECTIVE</b>To summarize the diagnosis and treatment of acute rejection after lung transplantation and to discuss optimized immunosuppressive therapy.</p><p><b>METHODS</b>Between November 2002 and June 2006, 16 patients underwent operations on lung transplantation, 7 cases on single-lung transplantation and 9 cases on bilateral-lung transplantation. Immunosuppressive therapy was new triple drug maintenance regimen including tacrolimus (Tac), mycophenolate mofetil (MMF) and steroids, and (or) daclizumab.</p><p><b>RESULTS</b>Eight cases in new triple drug maintenance regimen with daclizumab. There is no acute rejection in 6 months. Except 2 of the 8 cases died of early post-lung transplantation sever pulmonary edema and dysfunction, 3 of the rest 6 cases underwent acute rejection incident about 21.4% (3/14).</p><p><b>CONCLUSION</b>In this group the new triple drug maintenance regimen including tacrolimus (Tac), mycophenolate mofetil (MMF) and steroids, and (or) daclizumab acquired beneficial effect in preventing acute rejection after lung transplantation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Complications
/
Immunoglobulin G
/
Prednisone
/
Lung Transplantation
/
Treatment Outcome
/
Tacrolimus
/
Therapeutic Uses
/
Antibodies, Monoclonal, Humanized
/
Graft Rejection
/
Immunosuppressive Agents
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2007
Type:
Article
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