Comparative study on using TTCP and CTCP ceramic artificial bone for repairing segment defect of long bone / 生物医学工程学杂志

ABSTRACT

To develop ideal ceramic artificial bone for accelerating the process of repairing segment defect of long bone, tubing tricalcium phosphate (TTCP) and column tricalcium phosphate (CTCP) ceramic artificial bones were implanted separately into radial defects of 1 cm in adult rabbits. Specimens were taken in 4 and 12 weeks. The samples were examined by gross histomorphological observation, quantitative measurement of new bone formation and bending strength. The amount of new bone formation in TTCP was more than that in CTCP at 4 and 12 weeks postoperatively. At 12 weeks after operation, the grafted materials were bonded closely with host bone. The degradation rate of TTCP was faster than that of CTCP, and the bending strength of TTCP was stronger than that of CTCP(P < 0.01). The results showed that the design of TTCP is relatively rational and TTCP could accelerate the repair of segment defect of long bone more rapidly than CTCP. TTCP is an ideal artificial bone material.