Mediation of abdominal obesity on the association between cigarette smoking and β-cell function / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 988-991, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-341018
ABSTRACT
Objective To confirm the effect of cigarette smoking on β-cell function, and further investigate the mediation effect of abdominal obesity. Methods Participants would include 1440 Chinese smokers who had participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007. They were interviewed with structured questionnaire on their socio-demographic status and smoking behaviors. Waist-to-hip ratio (WHR) and fasting serum C-peptide concentration were also measured. Results After adjustment for the potential confounding factors, when compared with smokers with consumption 1-10 cigarettes/day, smokers with consumption of 11-20 cigarettes/day (adjusted OR=1.53, 95%CI 1.22-1.90) or >20 cigarettes/day (adjusted OR=1.92, 95%CI 1.32-2.79) had significant higher risks to get C-peptide concentration larger than its median. Furthermore, 37.54% of the effect of cigarette smoking on C-peptide concentration was partially mediated by abdominal obesity. Conclusion Cigarette smoking might be a risk factor for β-cell dysfunction and abdominal obesity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Qualitative research
/
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2010
Type:
Article
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