Using two-stage case-control designs to study the genome-wide association / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1184-1187, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-341052
ABSTRACT
Genome-wide association study is an important approach to identify common genetic variants that predispose to human disease. Because of the high cost of genotyping on hundreds of thousands of markers on thousands of subjects, a more cost-effective two-stage case-control design is applied by most genome-wide association studies. To describe the design and statistical methods of the two-stage case-control study, this paper introduces the principles of two-stage case-control design, its implementing steps in genome-wide association study and the features of its application.The method is illustrated with an example.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Observational study
/
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2010
Type:
Article
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