Value of 18F fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in diagnosis and localization of Cushing's disease / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 107-110, 2011.
Article
in English
| WPRIM
| ID: wpr-341449
ABSTRACT
<p><b>OBJECTIVE</b>To explore the value of [18F]fluoro-2-deoxy-D-glucose(18 FDG) positron emission tomography and computer tomography (PET/CT) in the qualitative diagnosis and localization of Cushing's disease.</p><p><b>METHODS</b>Totally 12 patients underwent transsphenoidal adenomectomy and were histopathologically proven to be with Cushing's disease. 18FDG PET/CT whole-body and brain scannings were performed preoperatively; meanwhile, magnetic resonance imaging (MRI) and 99mTc-octreotide examination were done in all 12 cases, and inferior petrosal sinus sampling (IPSS) were done in 6 patients.</p><p><b>RESULTS</b>The sensitivity of 18FDG in diagnosing Cushing's disease was 91.6% (11/12), but MRI was 66.7%(8/12). For the 6 patients who performed IPSS, 5 of them was diagnosed to be with Cushing's disease, and only 50% (3/6) were localized correctly in the pituitary gland.</p><p><b>CONCLUSIONS</b>18FDG PET/CT whole-body scan can exclude ectopic adrenocorticotropin-secreting tumors and localize the pituitary lesions with higher accuracy than MRI. Therefore, it is useful for suspected Cushing's disease, especially for patients their MRI and IPSS have negative or paradoxical results.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Diagnostic Imaging
/
Magnetic Resonance Imaging
/
Tomography, X-Ray Computed
/
Sensitivity and Specificity
/
Fluorodeoxyglucose F18
/
Pituitary ACTH Hypersecretion
/
Positron-Emission Tomography
/
Multimodal Imaging
/
Methods
Type of study:
Diagnostic study
/
Qualitative research
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2011
Type:
Article
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