Application of dual-energy computed tomography for detecting uric acid deposition in patients with gout / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 645-648, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-341483
ABSTRACT
<p><b>OBJECTIVE</b>To assess the value of dual energy computed tomography (DECT) for the detection of uric acid (UA) deposition in patients with gout.</p><p><b>METHODS</b>A total of 37 patients with tophaceous gout (including 8 crystal-proven cases) and 10 control patients (5 with unknown arthropathy, 3 with rheumatoid arthritis, and 2 with osteoarthritis) were included. DECT was performed for all peripheral joints (wrists, hands, elbows, knees, ankles and feet) . Color coding was used to display the localization of UA deposition. Images were reviewed independently by two trained radiologists.</p><p><b>RESULTS</b>With DECT, patients with gout were found to have UA deposits in hands and wrists 46% (17/37) , elbows 16% (6/37) , knees 27% (10/37) , ankles and feet 89% (33/37) . No UA deposit was observed in all 10 control patients (P=0.000) . Among the 37 patients with gout, the number of UA deposition sites detected by DECT (n=297) was 2.25 times of that detected by physical examinations (n=132) (P=0.000) .</p><p><b>CONCLUSIONS</b>DECT allows the visualization of UA deposition in gouty arthropathy. Even subclinical disease can be delineated with this technique. However, the accuracy of DECT requires further investigations.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Uric Acid
/
Diagnostic Imaging
/
Arthrography
/
Tomography, X-Ray Computed
/
Sensitivity and Specificity
/
Extremities
/
Gout
/
Metabolism
/
Methods
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2010
Type:
Article
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