Risk factors for the perineal incision complications after abdominoperineal excision for rectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 396-400, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-341517
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the factors affecting perineal incision complications after abdominperineal excision(APE) for rectal cancer.</p><p><b>METHODS</b>This was a retrospective study of 167 patients with rectal cancer undergoing APE at Peking University People's Hospital between October 1998 and December 2013. Chi-square test and multivariate Logistic regression analysis were used to identify risk factors.</p><p><b>RESULTS</b>The overall rate of perineal incision complication was 24.6%(41/167) including 7 cases of incision infection, 10 cases of incision fat liquefaction, 21 cases of poor wound healing, 2 cases of incision fistula, 1 case of incision dehiscence. In univariate analysis, the risk factors associated with perineal incision complication were operating time≥280 minutes(P=0.005), blood loss≥350 ml(P=0.017) and the protective factors associated with perineal incision complication were the procedure of APE (P=0.048), intraperitoneal chemotherapy with 5-FU sustained release (P=0.014), lymph node metastasis (P=0.006), while gender, age, BMI, ASA score, other complications, distance from distal tumor to anal verge, preoperative radiochemotherapy, postoperative stay in ICU, total drainage volume 3 days before operation, tumor differentiation, and postoperative TNM staging were not associated with perineal incision complication(all P>0.05). Multivariate logistic regression analysis identified two independent risk factors operating time≥280 minutes(OR=5.217, 95% CI1.250 - 6.234, P=0.000), intraperitoneal chemotherapy with 5-FU sustained release(OR=3.284, 95% CI1.156 - 9.334, P=0.026).</p><p><b>CONCLUSIONS</b>Operating time≥280 minutes and intraperitoneal chemotherapy with 5-FU sustained release are independent risk factors for perineal incision complications after APE for rectal cancer. For patients receiving APE procedure, intraperitoneal chemotherapy with 5-FU sustained release should be used with caution, and the operative time should be reduced when possible.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perineum
/
Postoperative Complications
/
Rectal Neoplasms
/
Rectum
/
General Surgery
/
Digestive System Surgical Procedures
/
Surgical Wound Infection
/
Epidemiology
/
Retrospective Studies
/
Risk Factors
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2016
Type:
Article
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