Value of Glasgow prognostic score in patients with adenocarcinoma of esophagogastric junction / 中华胃肠外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the prognosis and predictive values of preoperative Glasgow prognostic score (GPS) for adenocarcinoma of esophagogastric junction(AEG) patients.</p><p><b>METHODS</b>A retrospective study of 322 AEG patients who received operation between January 2007 and March 2010 in Henan Provincial People's Hospital was performed. Clinical data, pathological characteristics, laboratory parameters and survival data were collected. The GPS was calculated based on C-reactive protein(CRP) and serum albumin(ALB) levels. Univariate and multivariate analysis were used to evaluate the prognostic value of GPS.</p><p><b>RESULTS</b>Among 322 patients, 0, 1, 2 of GPS were 192, 104 and 26 patients respectively. The median follow-up was 37 (4-73) months. In Kaplan-Meier analysis, median diseases-free survival (DFS) of GPS 0, 1, 2 was 47.0 (95% CI 31.6-62.4), 15.0 (95% CI 11.8-8.2) and 4.7 (95% CI 3.8-5.6) months (P<0.01), and median overall survival (OS) was out of reach, 20.6 (95% CI 15.8-25.4) and 7.0 (95% CI 5.8-8.2) months (P<0.01). Univariate and multivariate analysis revealed that GPS was an independent predictor of DFS (P<0.01) and OS (P<0.01) of AEG.</p><p><b>CONCLUSION</b>GPS is an effective predictor of survival in AEG.</p>