In vitro study on physical and chemical properities of calcium phosphate cement/amifostine complex and on vitality of cultured cells / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 337-341, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-341622
ABSTRACT
This study was designed to assess the feasibility of calcium phosphate cement/amifostine complex as a new material for filling the bone defect caused by tumor resection. Mixed-molding method was used, the mass ratios of 0%, 0.1%, 0.5%, 1%, 2% of amifostine/calcium phosphate cement complex being adopted. The curing time, mechanical strength, porosity, scanning electron micrograph, osteosarcoma cells' vitality and vascular endothelial cells' vitality relevant to the complex in vitro were observed. Calcium phosphate cement being loaded with 0.1% and 0.5% amifostine did not affect the curing time, strength, pore size and porosity of calcium phosphate bone cement. In addition proliferation and differentiation of osteosarcoma cells and vascular endothelial cells were not affected. These data suggest that phosphate cement containing 0.1% and 0.5% amifostine be of significance in the treatment regimen as bone defect filling materials..
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Bone Cements
/
Calcium Phosphates
/
Osteosarcoma
/
Cell Survival
/
Cells, Cultured
/
Amifostine
/
Cell Biology
/
Cell Line, Tumor
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2010
Type:
Article
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