A non-invasive glucose measurement method based on orthogonal twin-polarized light and its pilot experimental investigation / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 278-282, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-341635
ABSTRACT
In order to overcome the existing shortcomings of the non-invasive blood glucose polarized light measurement methods of optical heterodyne detection and direct detection, we present in this paper a new orthogonal twin-polarized light (OTPL) non-invasive blood glucose measurement method, which converts the micro-angle rotated by an optical active substance such as glucose to the energy difference of OTPL, amplifies the signals by the high-sensitivity lock-in amplifier made of relevant principle, controls Faraday coil current to compensate the changes in deflection angle caused by blood glucose, and makes use of the linear relationship between blood glucose concentration and Faraday coil current to calculate blood glucose concentration. In our comparative experiment using the data measured by LX-20 automatic biochemical analyzer as a standard, a 0.9777 correlation coefficient is obtained in glucose concentration experiment, and a 0.952 in serum experiment. The result shows that this method has higher detection sensitivity and accuracy and lays a foundation for the development of practical new type of non-invasive blood glucose tester for diabetic patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Optical Rotation
/
Polarography
/
Blood
/
Blood Glucose
/
Blood Glucose Self-Monitoring
/
Pilot Projects
/
Diabetes Mellitus
/
Optics and Photonics
/
Methods
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2010
Type:
Article
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