The effects of hypoxic-ischemia on glutamate transporters / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 202-205, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-341653
ABSTRACT
Glutamate is a kind of excitatory transmitter in the central nervous system of mammals; at the same time, being with excitatory toxicity, its extracellular concentration is mainly modulated by the glutamate transporters. In the case of hypoxic-ischemia, the energy failure would lead to the generation of lactate and free radical, and to the crash of [Na+] gradient, thus exerting influence on the activity and the expression of glutamate transporters. As a result, the glutamate accumulates in the synaptic cleft, activates the glutamate receptors, and causes the death of neurons.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Synapses
/
Synaptic Transmission
/
Glutamic Acid
/
Hypoxia-Ischemia, Brain
/
Amino Acid Transport System X-AG
/
Glutamate Plasma Membrane Transport Proteins
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2010
Type:
Article
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