Preparation and release exam of magnetic chitosan nano-spheres of doxorubicin / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 86-90, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-341676
ABSTRACT
Magnetic chitosan (CS) nano-spheres were prepared by the modified suspension cross-linking technique. The results demonstrated that the magnetic drug nano-spheres are mainly spherical in form with a size of 200 to 800 nm, and show good magnetic responsivity. Here, Doxorubicin was used as exam drug. Glutaraldehyde connects Doxorubicin to CS by the chemical bond (-N = C-), and the drug content is in range of 1% to 15% (w/w). The chemical bond is broken depending on pH, so pH is the important factor for the release of doxorubicin. The doxorubicin release was 22.0%, 13.4%, and 4.1% in the space of 7d, when pH was 1, 2, 4. So the nano-spheres are pH-sensitive magnetic targeting drug micro-spheres.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drug Carriers
/
Doxorubicin
/
Chemistry
/
Drug Delivery Systems
/
Chitosan
/
Nanospheres
/
Magnetics
/
Methods
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2010
Type:
Article
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