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Application of multicomponent dissolution evaluation method of biopharmaceutics classification system of Chinese materia medica in gegen qinlian tablets / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 4494-4498, 2014.
Article in Chinese | WPRIM | ID: wpr-341791
ABSTRACT
The study is a paticular embodiment of Chinese patent medicine based on biopharmaceutics classification system of Chinese materia medica (CMMBCS) , focusing on assessment of synchronization issues of dissolution that may affect the timing of the multicomponent absorption. The accumulative dissolution percentages of nine components in Gengen Qinlian tablets in different dissolution solvents and times were determined by HPLC. The dissolution curve was drew and its similarity was evaluated by similarity factors (f2) and cluster method. Results in this experiment showed that the components that peak 7 and peak 8 (baicalin) represented had poor similarity with the reference peak 2 (puerarin). Their similarity factors were both 43 in water dissolution media and 31 and 45 in pH 7.4 dissolution media, respectively. Components that peaks represented had better similarity with the reference peak 2 (puerarin) in other medium. It illustrated that components that peak 3,4,5,6 (berberine) represented had fully synchronous dissolution characteristics with the reference peak 2 (puerarin), components peak 1 and 9 represented had nearly fully synchronous dissolution characteristics with the reference peak 2 (puerarin), while components that peak 7 and 8 (baicalin) represented had no synchronous dissolution characteristics with the reference peak 2 (puerarin).
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Solubility / Tablets / Biopharmaceutics / Drugs, Chinese Herbal / Chemistry / Chromatography, High Pressure Liquid / Classification / Hydrogen-Ion Concentration Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Solubility / Tablets / Biopharmaceutics / Drugs, Chinese Herbal / Chemistry / Chromatography, High Pressure Liquid / Classification / Hydrogen-Ion Concentration Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2014 Type: Article