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Design and analyze mathematical algorithms of intestinal absorption and metabolism of multicomponent drug / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-341793
Responsible library: WPRO
ABSTRACT
Evaluation of the permeability mainly focuses on intestinal absorption in biopharmaceutics classification system (BCS). It is more complicated that the absorption and metabolism under multicomponent environment in biopharmaceutics classification system of Chinese materia medica (CMMBCS) compared with single component environment, which needs suitable mathematical models to be described. Therefore, with full consideration of existing single component mathematical algorithm combining with the characteristics of intestinal absorption and metabolism, we explored and designed a new mathematical algorithm of intestinal absorption and metabolism of multicomponent drug. Then we put forward a new coefficient, P (influence), the relative change rate of the single component's intestinal absorption and metabolism under multicomponent environment compared with single component environment, which described the influences of intestinal absorption and metabolism of the component under multicomponent environment. Moreover, P (influence) highlights the distinctive characteristics of multicomponent drug's intestinal absorption and metabolism, and lays the foundation for the construction of CMMBCS.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Solubility / Algorithms / Humans / Drugs, Chinese Herbal / Pharmacokinetics / Chemistry / Intestinal Absorption / Intestines / Metabolism / Models, Theoretical Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2014 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Solubility / Algorithms / Humans / Drugs, Chinese Herbal / Pharmacokinetics / Chemistry / Intestinal Absorption / Intestines / Metabolism / Models, Theoretical Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2014 Type: Article