Study on molecular mechanism of Euodiae Fructus on liver toxicity in MICE / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4865-4868, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-341801
ABSTRACT
<p><b>OBJECTIVE</b>To study the molecular mechanism of extracts from Euodia rutaecarpa on hepatotoxicity in mice.</p><p><b>METHOD</b>Totally 30 KM mice were divided into 3 groups and orally administrated extracts from E. rutaecarpa for consecutively 15 days. The expressions of Erkl/2, CDK8, CK1e, Stat3 and Src were detected by Western blotting method.</p><p><b>RESULT</b>The extracts from E. rutaecarpa could up-regulated Erkl/2, CDK8 and CK1e expressions (P <0.01) and down-regulate Stat3 and Src (P <0.01).</p><p><b>CONCLUSION</b>The molecular mechanism of E. rutaecarpa on hepatotoxicity may be correlated with Erkl/2, CDK8, CKle, Stat3 and Src signal molecules.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Aspartate Aminotransferases
/
Triglycerides
/
Blood
/
Drugs, Chinese Herbal
/
Signal Transduction
/
Down-Regulation
/
Up-Regulation
/
Chemistry
/
Gene Expression Regulation
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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