Investigation on release model of insoluble drug in hydroxypropyl methycellulose matrix tablets / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 225-228, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-341901
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the release model of insoluble drug carbamazepine (CBM) based on HPMC matrix tablets.</p><p><b>METHODS</b>CBM release profile from matrices and HPMC erosion rate were determined.</p><p><b>RESULT</b>The mathematical model by matrix erosion rate and drug release from HPMC K15M were established for the fractional HPMC and CBM released as M(P(t))/M(P(infinity))=-[0.8095ln((t))+1.2775]Meq((-0.0622t-0.305)) and M(d(t))/M(d(infinity))=-[0.1891t-0.1294]Meq(-0.9326). In comparison with the data of HPMC K4M matrix erosion and CBM release from HPMC K4M matrices, theoretical value agreed well with experimental data.</p><p><b>CONCLUSION</b>The two mathematical models can be satisfactorily applied to insoluble drug release, which is governed by matrix erosion.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Solubility
/
Tablets
/
Carbamazepine
/
Chemistry
/
Delayed-Action Preparations
/
Hypromellose Derivatives
/
Methylcellulose
/
Models, Theoretical
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2004
Type:
Article
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